• Lactate induced GPR activation was confirmed with a fluorime

  2022-08-12

  

  Lactate-induced GPR81 activation was confirmed with a fluorimetric imaging plate reader (FLIPR) assay, in which lactate induced a [Ca2+] flux in CHO cells stably expressing Gqi5 and HA-GPR81 but not vector control (Fig. 1C). The EC50 of lactate in the FLIPR assay was 4.3±0.73mM, a value well within

• Thus synthesized thienopyrimidine derivatives were

  2022-08-12

  

  Thus synthesized thienopyrimidine derivatives were evaluated in vitro for GPR119 agonistic activity, and the results are summarized in , , . First, we fixed the 4-methylsulfonylphenyl substituent at the R position on the thienopyrimidine ring, and derivatized at the R position. As shown in , and s

• Mongolian gerbils Meriones unguiculatus a social

  2022-08-12

  

  Mongolian gerbils (Meriones unguiculatus), a social rodent species, are widely distributed in the typical steppe, desert steppe and desert habitats of northern China, Mongolia, and Trans-Baikal region of Russia. In wild, the recorded maximum lifespan (apparent longevity) was 29.5 months for female M

• Here we performed TEM and

  2022-08-12

  

  Here, we performed TEM and AFM imaging to study APE1–DNA interactions. The results showed that APE1 can dynamically polymerize on DNA in an apparently sequence-independent manner. We propose that this protein polymerization allows for scanning of the structural properties of DNA with short residence

• br NMDA receptor LBDs The study of GluA

  2022-08-12

  

  NMDA receptor LBDs The study of GluA2 was later expanded to include NMDA receptors [22]. NMDA receptors are obligate heterotetramers that are composed of two glutamate-binding subunits and two glycine-, or d-serine-, binding subunits. In this study, crystal structures of the NMDA receptor glycine

• br NLS and NES Mapping br Sequence

  2022-08-12

  

  NLS and NES Mapping Sequence Comparison of Gli NLSs—NLSs in ZF Domains Alignment of the Gli NLSs of representative metazoan animals suggests that the amino TC-I 15 receptor residues in the ZF domains are strongly conserved (Figure 4.2, Figure 4.3B). However, the length of the intervening amino

• So in this study our results firstly

  2022-08-12

  

  So in this 8-pCPT-2-O-Me-cAMP-AM study , our results firstly demonstrated that i.c.v. injection of ghrelin(1–7)-NH2 played a significant role in the modulation of the acute heat pain at the supraspinal level in mice. Our results showed that i.c.v. injection of ghrelin(1–7)-NH2 produced dose- and tim

• br Ghrelin Ghrelin was purified from rat stomach about

  2022-08-12

  

  Ghrelin Ghrelin was purified from rat stomach about twenty years ago as a 28-amino URB597 octanoylated peptide and shown to be the endogenous ligand of the growth hormone (GH) secretagogue receptor (now termed GHSR1a, Howard et al., 1996, Kojima et al., 1999). GHSR1a is a 7-transmembrane recepto

• Occupying at least of brain volume astroglial cells not

  2022-08-11

  

  Occupying at least 50% of Cyanine 3-dUTP volume, astroglial cells not only possess a high level of association in network through gap junctions and direct intercellular communications [28], but also are extensively exposed to extracellular fluid and contribute in shaping different types of synapses

• Compounds and were evaluated for their pharmacokinetic prope

  2022-08-11

  

  Compounds and were evaluated for their pharmacokinetic properties in rats and the results are summarized in . Following intravenous (IV) administration, both compounds displayed low clearance (CL), short half-lives (t) and low volumes of distribution (V). When dosed orally as a solution, exposure

• a-MSH, amide Migration chemotaxis and trafficking of leukocy

  2022-08-11

  

  Migration, chemotaxis and trafficking of leukocytes, including eosinophils from the peripheral blood into the site of inflammation requires their adhesion to endothelial a-MSH, amide (Ley et al., 2007). Despite ongoing research, the histamine effect on eosinophils adhesion to endothelium cells has n

• The current research also analyzed

  2022-08-11

  

  The current research also analyzed the association of this polymorphism with HCV genotype 1-related hepatic steatosis by gender. Even though the allele and genotypes of this polymorphism an increased the risk of HCV-related hepatic steatosis, neither allele nor genotype frequency of this polymorphis

• br Structural studies of GCAP Recoverin was

  2022-08-11

  

  Structural studies of GCAP Recoverin was the first member of this subfamily of Ca2+-binding 740 Y-P to be investigated by structural methods [27], [54], [55], [56], [57], [58]. These proteins have four EF-hands arranged in pairs that give rise to amino- and carboxyl-terminal domains. The crystal

• Ras small GTPases are critical

  2022-08-11

  

  Ras small GTPases are critical molecular switches that connect extracellular signals to intracellular signaling pathways initiated by membrane receptors, such as growth factor receptors and G protein-coupled receptors (Simanshu et al., 2017). When shifting between active GTP-bound and inactive GDP-b

• In this study we also investigated the role of

  2022-08-11

  

  In this study, we also investigated the role of GST AH 7614 in relation to ASD. In univariable analyses, where the role of each GST gene (i.e., GSTM1, GSTT1, GSTP1) was individually assessed, we did not observe any significant associations between the GST genotypes and ASD. In contrast, a previous s

16062 records 415/1071 page Previous Next First page 上5页 411412413414415 下5页 Last page