• The indigenous populations living at high

  2021-04-16

  

  The indigenous populations living at high mountain regions of the Himalayas represent successful human urokinase to hypoxia. These populations have undergone selective positive natural selection over millennia across several genomic loci and exhibit unique respiratory, cardiopulmonary and haematolog

• The different serotypes A G have

  2021-04-16

  

  The different serotypes (A-G) have unique receptors to which they bind to produce the toxic effect on the nerve cells. (Lance, 2004, Rosetto et al., 2014). Intracellularly, the endopeptidase activity of different serotypes of BoNT target selectively a unique group of proteins, the SNARE streptozotoc

• Nimodipine is an L type calcium

  2021-04-16

  

  Nimodipine is an L-type calcium channel antagonist that reduces excessive calcium influx during pathological conditions, contributing to its neuroprotective properties (Zornow and Prough, 1996; Kobayashi and Mori, 1998). Autophagy can be induced by increased [Ca2+] (Rami et al., 2008). Nimodipine si

• Although PKC in cancer cells is known to promote antiapoptot

  2021-04-16

  

  Although PKCδ in cancer DCG IV is known to promote antiapoptotic signaling, a cleaved form of PKCδ, δCF, has been reported to play a contrasting role in enhancing apoptosis (Reyland, 2007), and these complex functions appear to be cell-type dependent (Basu and Pal, 2010). In NSCLC, full-length PKCδ

• Introduction Innate lymphoid cells ILCs are recently describ

  2021-04-16

  

  Introduction Innate lymphoid atp gamma s receptor (ILCs) are recently described immune cells of lymphoid origin and include cytotoxic natural killer (NK) cells and interleukin-7 receptor alpha (also known as CD127)+ subsets, which, similar to T helper (Th) lymphocytes, can be distinguished on the b

• Modulating protein stability specifically inhibiting ubiquit

  2021-04-16

  

  Modulating protein stability, specifically inhibiting ubiquitin E3 ligases, provides potential advantages over other druggable targets given the presence of biochemically multiple, unique pharmacophores within complexes that can bind a variety of small molecules [12]. The FBXO3 inhibitors used here

• In general cellular senescence is

  2021-04-16

  

  In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200

• In laboratory strains of Escherichia coli three mechanisms o

  2021-04-16

  

  In laboratory strains of Escherichia coli, three mechanisms of repair for alkylated bases are known. The first involves constitutively expressed Ogt and inducible Ada methyltransferases, directly removing methyl groups from O6-methylguanine (O6meG) and O4-methylthymine (O4meT) [1], [2], [3], [4]. In

• Introduction The Discoidin Domain Receptors DDRs comprising

  2021-04-15

  

  Introduction The Discoidin Domain Receptors (DDRs), comprising DDR1 and DDR2, are collagen-binding receptor tyrosine kinases (RTKs) that function as microenvironmental sensors at the interface of the extracellular matrix and the intracellular signal transduction machinery [1]. In response to ligand

• The role of ARA cyp metabolites in

  2021-04-15

  

  The role of ARA-cyp450 metabolites in the liver is still unclear [44]. However, ARA-cyp450 genes metabolize other fatty acids such lauric and palmitic Naltrindole hydrochloride [45]. It was found that decreased cyp4a expression caused fatty livers through reduction of fatty acid metabolism [46]. In

• br Making the BN Cox model computationally efficient

  2021-04-15

  

  Making the BN-Cox model computationally efficient One of the challenges to applying the BN-Cox model is an exponential growth of the conditional probability tables (CPT) corresponding to the survival variables, as the number of risk factors increases [22]. When the number of risk factors is high,

• Epoxomicin Materials and methods br Results br Discussion Hy

  2021-04-15

  

  Materials and methods Results Discussion Hydroxylation of proline in bacterial Epoxomicin is one of the oxygen-requiring metabolic reactions, which needs efficient oxygen. Oxygen supply is always a rate-limiting step for tyrosinase production even though pure oxygen is purged in a bioreactor

• chembridge br Materials and methods br Results br Discussion

  2021-04-15

  

  Materials and methods Results Discussion A reporter of FGF signaling activity has long been sought to facilitate the quantitative real-time analysis of pathway activity at single-cell resolution. Here we report the generation of a Spry4 reporter allele in ESCs and mice that recapitulates kn

• br The orphan estrogen related receptor exists

  2021-04-15

  

  The orphan estrogen-related receptor exists as three subtypes (ERRα, ERRβ, and ERRγ) in the human genome. ERRα is expressed in metabolically active tissues such as muscle and adipose. ERRγ is expressed in the spinal cord and CNS. ERRβ appears to play a role in development, as postnatal expression

• Recently roflumilast has been approved as the first selectiv

  2021-04-15

  

  Recently, roflumilast has been approved as the first selective PDE4 inhibitor for the treatment of chronic obstructive pulmonary disease (COPD) [2]. Roflumilast has been suggested to target several different pathogenetic mechanisms, including inflammation, fibrotic, emphysematous and vascular remode

16062 records 692/1071 page Previous Next First page 上5页 691692693694695 下5页 Last page