• Our recent QTL mapping study

  2020-08-10

  

  Our recent QTL mapping study revealed that the adaptor genes, including the NCK genes and the ABI genes, are located within the genomic regions harboring the most significant QTL (Zhou et al., 2017), suggesting that these genes could be involved in the determination of resistance, and possibly throu

• There has recently been some interest in

  2020-08-10

  

  There has recently been some interest in Uba6, which is most similar to slime mold, with BLAST identities of 59% and positives 73% in the 400–600 ADD range. The 400–600 ADD correlation of the two profiles is a striking 87%, so functional differences probably arise outside the ADD binding domain. Hu

• Enolase is an example of a

  2020-08-10

  

  Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties. It has also been described as a complement-evasion protein and as a protein capable of inducing neutrophil trap formation.

• The AURA trial was a phase I

  2020-08-10

  

  The AURA trial was a phase I/II study evaluating the safety, tolerability and activity of Osimertinib in patients with EGFR-mutated NSCLC progressing after a previous EGFR TKI. The phase I component of the study included a dose escalation part (Osimertinib 20mg to 240mg), using a rolling six design,

• In conclusion the results obtained in this study and those

  2020-08-08

  

  In conclusion, the results obtained in this study and those recently reported by our group (Abdel-Samad et al., 2012) clearly indicate that a dialogue indeed exists between the systems of NPY and ET-1 at the level of human endocardial endothelial cells, since these cells, whether isolated from the r

• br Experimental br Biological assay method br

  2020-08-08

  

  Experimental Biological assay method Introduction Prostanoid receptors are known to be members of the G-protein coupled receptor superfamily. Recently, eight prostanoid receptors (EP1, EP2, EP3, EP4, IP, TP, DP, and FP) have been cloned and characterized. The characterization of these recep

• br Materials and methods br Results Assay of botulinum toxin

  2020-08-08

  

  Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases. The frequently encountered active forms of the toxin are; L chain (inside intoxicated neuronal cells), BoNT (in the blood stream of a botulism patien

• The innate immune system ensures virus inhibition until the

  2020-08-07

  

  The innate immune system ensures virus inhibition until the adaptive immune system is ready to launch a much more comprehensive antiviral response, which mainly consists of cytotoxic CD8 T Z-LEHD-FMK and antibody production induced by CD4+ T cells to a minor degree. Initially, cytotoxic T cells (CT

• We also provide evidence that in order to promote

  2020-08-07

  

  We also provide evidence that in order to promote collagen production, DDR1 requires collagen binding as mutation of R105 in the collagen binding site significantly decreases the ability of DDR1 to stimulate collagen production at baseline and/or following collagen stimulation. Thus, it is conceivab

• Lomustine Transport of proteins into the nucleus through the

  2020-08-06

  

  Transport of proteins into the nucleus through the nuclear pore complex can be facilitated by the dedicated nuclear transport receptors of the β-karyopherin family, which includes the importins [23]. Proteins able to translocate by use of importins contain one or more nuclear localisation signals (N

• Adipose tissue can be divided into at least two metabolicall

  2020-08-06

  

  Adipose tissue can be divided into at least two metabolically-distinct types: brown adipose tissue (BAT) and white adipose tissue (WAT). BAT is primarily an energy expending tissue, whose human relevance has recently become an active area of research [3], [4]. White adipose tissue, in contrast, is p

• br Acknowledgements The study of RING type E s continues

  2020-08-06

  

  Acknowledgements The study of RING-type E3s continues to grow extremely rapidly. We regret that it was possible to only cite a fraction of the outstanding primary publications in this field. This work was supported by the National Institute of General Medical Sciences grants R01 GM088055 and R01

• br Biological functions For CcPDH the

  2020-08-06

  

  Biological functions For CcPDH, the occurrence of the non-catalytic, cellulose binding domain indicates a role in plant cell wall degradation, a complex process carried out by the synergistic action of hydrolases and oxidoreductases []. Interestingly, CcPDH shows the highest oxidative activity to

• In conclusion MEN behave as a potent and

  2020-08-06

  

  In conclusion, MEN91507 behave as a potent and selective CysLT1antagonist in guinea-pigs and human in vitro assays. In vivo, MEN91507 shares with the other CysLT1 antagonists anti-bronchospastic and anti-inflammatory effects; since these effects are long-lasting and are also observed following the o

• Similar to PGD nearly all of the CRTH

  2020-08-06

  

  Similar to PGD2, nearly all of the CRTH2 antagonists are carboxylic PD 151746 derivatives with a carboxylate moiety, which is believed to be a critical pharmacophore that interacts with the receptor (Pettipher and Whittaker, 2012) (Figure 1A). To understand the molecular mechanisms for the action o

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